Why is there concern that cell phones may cause cancer or other health problems?
There are three main reasons why people are concerned that cell phones (also known as “mobile” or “wireless” telephones) might have the potential to cause certain types of cancer or other health problems:
The NCI fact sheet Electromagnetic Fields and Cancer includes information on wireless local area networks (commonly known as Wi-Fi), cell phone base stations, and cordless telephones.
What is radiofrequency radiation and how does it affect the human body?
Radiofrequency radiation is a form of electromagnetic radiation. Electromagnetic radiation can be categorized into two types: ionizing (e.g., x-rays, radon, and cosmic rays) and non-ionizing (e.g., radiofrequency and extremely low frequency, or power frequency). Electromagnetic radiation is defined according to its wavelength and frequency, which is the number of cycles of a wave that pass a reference point per second. Electromagnetic frequencies are described in units called hertz (Hz).
The energy of electromagnetic radiation is determined by its frequency; ionizing radiation is high frequency, and therefore high energy, whereas non-ionizing radiation is low frequency, and therefore low energy. The NCI fact sheet Electromagnetic Fields and Cancer lists sources of radiofrequency radiation. More information about ionizing radiation can be found on the Radiation page.
The frequency of radiofrequency electromagnetic radiation ranges from 30 kilohertz (30 kHz, or 30,000 Hz) to 300 gigahertz (300 GHz, or 300 billion Hz). Electromagnetic fields in the radiofrequency range are used for telecommunications applications, including cell phones, televisions, and radio transmissions. The human body absorbs energy from devices that emit radiofrequency electromagnetic radiation. The dose of the absorbed energy is estimated using a measure called the specific absorption rate (SAR), which is expressed in watts per kilogram of body weight.
Exposure to ionizing radiation, such as from x-rays, is known to increase the risk of cancer. However, although many studies have examined the potential health effects of non-ionizing radiation from radar, microwave ovens, cell phones, and other sources, there is currently no consistent evidence that non-ionizing radiation increases cancer risk in humans (2).
The only consistently recognized biological effect of radiofrequency radiation in humans is heating. The ability of microwave ovens to heat food is one example of this effect of radiofrequency radiation. Radiofrequency exposure from cell phone use does cause heating to the area of the body where a cell phone or other device is held (e.g., the ear and head). However, it is not sufficient to measurably increase body temperature. There are no other clearly established effects on the human body from radiofrequency radiation.
How is radiofrequency radiation exposure measured in epidemiologic studies?
Epidemiologic studies use information from several sources, including questionnaires and data from cell phone service providers, to estimate radiofrequency radiation exposure. Direct measurements are not yet possible outside of a laboratory setting. Estimates take into account the following:
What has epidemiologic research shown about the association between cell phone use and cancer risk?
Researchers have carried out several types of epidemiologic studies in humans to investigate the possibility of a relationship between cell phone use and the risk of malignant (cancerous) brain tumors, such as gliomas, as well as benign (noncancerous) tumors, such as acoustic neuroma (tumors in the cells of the nerve responsible for hearing that are also known as vestibular schwannomas), meningiomas (usually benign tumors in the membranes that cover and protect the brain and spinal cord), and parotid gland tumors (tumors in the salivary glands) (3).
In one type of study, called a case–control study, cell phone use is compared between people with these types of tumors and people without them. In another type of study, called a cohort study, a large group of people who do not have cancer at study entry is followed over time and the rate of these tumors in people who did and didn’t use cell phones is compared. Cancer incidence data can also be analyzed over time to see if the rates of brain tumors changed in large populations during the time that cell phone use increased dramatically. These studies have not shown clear evidence of a relationship between cell phone use and cancer. However, researchers have reported some statistically significant associations for certain subgroups of people.
Three large epidemiologic studies have examined the possible association between cell phone use and cancer: Interphone, a case–control study; the Danish Study, a cohort study; and the Million Women Study, another cohort study.
How the study was done: This is the largest health-related case–control study of cell phone use and the risk of head and neck tumors. It was conducted by a consortium of researchers from 13 countries. The data came from questionnaires that were completed by study participants.
What the study showed: Most published analyses from this study have shown no statistically significant increases in brain or other central nervous system cancers related to higher amounts of cell phone use. One analysis showed a statistically significant, although modest, increase in the risk of glioma among the small proportion of study participants who spent the most total time on cell phone calls. However, the researchers considered this finding inconclusive because they felt that the amount of use reported by some respondents was unlikely and because the participants who reported lower levels of use appeared to have a slightly reduced risk of brain cancer compared with people who did not use cell phones regularly (4–6).
An analysis of data from all 13 countries participating in the Interphone study reported a statistically significant association between intracranial distribution of tumors within the brain and self-reported location of the phone (7). However, the authors of this study noted that it is not possible to draw firm conclusions about cause and effect based on their findings.
Additional analyses of data from Interphone countries
An analysis of data from five Northern European countries in the Interphone study showed an increased risk of acoustic neuroma only in those who had used a cell phone for 10 or more years (8).
In subsequent analyses of Interphone data, investigators addressed issues of risk according to specific location of the tumor and estimated exposures. One analysis of data from seven of the countries in the Interphone study found no relationship between brain tumor location and regions of the brain that were exposed to the highest level of radiofrequency radiation from cell phones (9). However, another study, using data from five of the countries, reported suggestions of an increased risk of glioma and, to a lesser extent, of meningioma developing in areas of the brain experiencing the highest exposure (10).
How the study was done: This cohort study, conducted in Denmark, linked billing information from more than 358,000 cell phone subscribers with brain tumor incidence data from the Danish Cancer Registry.
What the study showed: No association was observed between cell phone use and the incidence of glioma, meningioma, or acoustic neuroma, even among people who had been cell phone subscribers for 13 or more years (11–13).
How the study was done: This prospective cohort study conducted in the United Kingdom used data obtained from questionnaires that were completed by study participants.
What the study showed: Self-reported cell phone use was not associated with an increased risk of glioma, meningioma, or non-central nervous system tumors. Although the original published findings reported an association with an increased risk of acoustic neuroma (14), this association disappeared after additional years of follow-up of the cohort (15).
In addition to these three large studies, other, smaller epidemiologic studies have looked for associations between cell phone use and cancer. These include:
Investigators have also conducted analyses of incidence trends to determine whether the incidence of brain or other cancers has changed during the time that cell phone use increased dramatically. These include:
What are the findings from experimental studies?
In 2011, two small studies were published that examined brain glucose metabolism in people after they had used cell phones. The results were inconsistent; whereas one study showed increased glucose metabolism in the region of the brain close to the antenna compared with tissues on the opposite side of the brain (29), the other study (30) found reduced glucose metabolism on the side of the brain where the phone was used.
The authors of these studies noted that the results were preliminary and that possible health outcomes from changes in glucose metabolism in humans were unknown. Such inconsistent findings are not uncommon in experimental studies of the biological effects of radiofrequency electromagnetic radiation in people (4). Some factors that can contribute to inconsistencies across such studies include assumptions used to estimate doses, failure to consider temperature effects, and lack of blinding of investigators to exposure status.
Another study investigated the flow of blood in the brain of people exposed to the radiofrequency radiation from cell phones and found no evidence of an effect on blood flow in the brain (31).
Because of inconsistent findings from epidemiologic studies in humans and the lack of clear data from previous experimental studies in animals, in 1999 the Food and Drug Administration nominated radiofrequency radiation exposure associated with cell phone exposures for study in animal models by the U.S. National Toxicology Program (NTP), an interagency program that coordinates toxicology research and testing across the U.S. Department of Health and Human Services and is headquartered at the National Institute of Environmental Health Sciences, part of NIH.
The NTP studied radiofrequency radiation (2G and 3G frequencies) in rats and mice (36, 37). This large project was conducted in highly specialized labs that specified and controlled sources of radiation and measured their effects. The rodents experienced whole-body exposures of 3, 6, or 9 watts per kilogram of body weight for 5 or 7 days per week for 18 hours per day in cycles of 10 minutes on, 10 minutes off. A research overview of the rodent studies, with links to the peer-review summary, is available on NTP website. The primary outcomes observed were a small number of cancers of Schwann cells in the heart and non-cancerous changes (hyperplasia) in the same tissues for male rats, but not female rats, nor in mice overall.
These experimental findings raise new questions as to the potential for radiofrequency radiation to result in cellular changes and offer potential avenues for further laboratory studies. Cancers in the heart are extremely rare in humans, where the primary outcomes of potential concern with respect to radiofrequency radiation exposure from cell phones are tumors in the brain and central nervous system. Schwann cells of the heart in rodents are similar to the kind of cells in humans that give rise to acoustic neuromas (also known as vestibular schwannomas), which some studies have suggested are increased in people who reported the heaviest use of cell phones. The NTP has stated that they will continue to study this exposure in animal models to further advance our understanding of the biological underpinnings of the effects reported above.
Another animal study, in which rats were exposed 7 days per week for 19 hours per day to radiofrequency radiation at 0.001, 0.03, and 0.1 watts per kilogram of body weight was reported by investigators at the Italian Ramazzini Institute (38). Among the rats with the highest exposure levels, the researchers noted an increase in heart schwannomas in male rats and non-malignant Schwann cell growth in the heart in male and female rats. However, key details necessary for interpretation of the results were missing: exposure methods, other standard operating procedures, and nutritional/feeding aspects. The gaps in the report from the study raise questions that have not been resolved.
Why are the findings from different studies of cell phone use and cancer risk inconsistent?
A few studies have shown some evidence of statistical association of cell phone use and brain tumor risks in humans, but most studies have found no association. Reasons for these discrepancies include the following:
What are other possible health effects from cell phone use?
A broad range of health effects have been reported with cell phone use. Neurologic effects are of particular concern in young persons since the brain is the primary exposed organ. However, studies of memory, learning, and cognitive function have generally produced inconsistent results (41–44).
What have expert organizations said about the cancer risk from cell phone use?
In 2011, the International Agency for Research on Cancer (IARC), a component of the World Health Organization, appointed an expert Working Group to review all available evidence on the use of cell phones. The Working Group classified cell phone use as “possibly carcinogenic to humans,” based on limited evidence from human studies, limited evidence from studies of radiofrequency radiation and cancer in rodents, and inconsistent evidence from mechanistic studies (4).
The Working Group indicated that, although the human studies were susceptible to bias, the findings could not be dismissed as reflecting bias alone, and that a causal interpretation could not be excluded. The Working Group noted that any interpretation of the evidence should also consider that the observed associations could reflect chance, bias, or confounding rather than an underlying causal effect. In addition, the Working Group stated that the investigation of risk of cancer of the brain associated with cell phone use poses complex methodologic challenges in the conduct of the research and in the analysis and interpretation of findings.
In 2011, the American Cancer Society (ACS) stated that the IARC classification means that there could be some cancer risk associated with radiofrequency radiation, but the evidence is not strong enough to be considered causal and needs to be investigated further. Individuals who are concerned about radiofrequency radiation exposure can limit their exposure, including using an ear piece and limiting cell phone use, particularly among children.
In 2018, the ACS issued a statement on the draft NTP reports noting that the findings were still inconclusive, and that, so far, a higher cancer risk in people has not been seen, but that people who are concerned should wear an earpiece when using a cell phone.
The National Institute of Environmental Health Sciences (NIEHS) states that the weight of the current scientific evidence has not conclusively linked cell phone use with any adverse health problems, but more research is needed.
The U.S. Food and Drug Administration (FDA) notes that studies reporting biological changes associated with radiofrequency radiation have failed to be replicated and that the majority of human epidemiologic studies have failed to show a relationship between exposure to radiofrequency radiation from cell phones and health problems. The FDA, which originally nominated this exposure for review by the NTP in 1999, issued a statement on the draft NTP reports released in February 2018, saying “based on this current information, we believe the current safety limits for cell phones are acceptable for protecting the public health.” FDA and the Federal Communications Commission share responsibility for regulating cell phone technologies.
The U.S. Centers for Disease Control and Prevention (CDC) states that no scientific evidence definitively answers whether cell phone use causes cancer.
The Federal Communications Commission (FCC) concludes that currently no scientific evidence establishes a definite link between wireless device use and cancer or other illnesses.
In 2015, the European Commission Scientific Committee on Emerging and Newly Identified Health Risks concluded that, overall, the epidemiologic studies on cell phone radiofrequency electromagnetic radiation exposure do not show an increased risk of brain tumors or of other cancers of the head and neck region (2). The Committee also stated that epidemiologic studies do not indicate increased risk for other malignant diseases, including childhood cancer (2).
What studies are under way that will help further our understanding of the possible health effects of cell phone use?
A large prospective cohort study of cell phone use and its possible long-term health effects was launched in Europe in March 2010. This study, known as COSMOS, has enrolled approximately 290,000 cell phone users aged 18 years or older to date and will follow them for 20 to 30 years (47, 48).
Participants in COSMOS will complete a questionnaire about their health, lifestyle, and current and past cell phone use. This information will be supplemented with information from health records and cell phone records.
The challenge of this ambitious study is to continue following the participants for a range of health effects over many decades. Researchers will need to determine whether participants who leave the study are somehow different from those who remain throughout the follow-up period.
Although recall bias is minimized in studies such as COSMOS that link participants to their cell phone records, such studies face other problems. For example, it is impossible to know who is using the listed cell phone or whether that individual also places calls using other cell phones. To a lesser extent, it is not clear whether multiple users of a single phone, for example family members who may share a device, will be represented on a single phone company account. Additionally, for many long-term cohort studies, participation tends to decline over time.
Has radiofrequency radiation from cell phone use been associated with cancer risk in children?
There are theoretical considerations as to why the possible risk should be investigated separately in children. Their nervous systems are still developing and, therefore, more vulnerable to factors that may cause cancer. Their heads are smaller than those of adults and consequently have a greater proportional exposure to the field of radiofrequency radiation that is emitted by cell phones. And, children have the potential of accumulating more years of cell phone exposure than adults do.
Thus far, the data from studies in children with cancer do not support this theory. The first published analysis came from a large case–control study called CEFALO, which was conducted in Denmark, Sweden, Norway, and Switzerland. The study included children who were diagnosed with brain tumors between 2004 and 2008, when their ages ranged from 7 to 19 years. Researchers did not find an association between cell phone use and brain tumor risk either by time since initiation of use, amount of use, or by the location of the tumor (21).
Several studies that will provide more information are under way. Researchers from the Centre for Research in Environmental Epidemiology in Spain are conducting another international case–control study—Mobi-Kids—that will include 2000 young people (aged 10–24 years) with newly diagnosed brain tumors and 4000 healthy young people. The goal of the study is to learn more about risk factors for childhood brain tumors.
What can cell phone users do to reduce their exposure to radiofrequency radiation?
The FDA has suggested some steps that concerned cell phone users can take to reduce their exposure to radiofrequency radiation (49):
Hands-free kits reduce the amount of radiofrequency radiation exposure to the head because the antenna, which is the source of energy, is not placed against the head (40). Exposures decline dramatically when cell phones are used hands-free.
Where can I find more information about radiofrequency radiation from my cell phone?
The FCC provides information about the specific absorption rate (SAR) of cell phones produced and marketed within the last 1 to 2 years. The SAR corresponds with the relative amount of radiofrequency radiation absorbed by the head of a cell phone user (50). Consumers can access this information using the phone’s FCC ID number, which is usually located on the case of the phone, and the FCC’s ID search form.
How common is brain cancer? Has the incidence of brain cancer changed over time?
In the United States, 23,820 new diagnoses and 17,760 deaths from brain and other central nervous system cancers are estimated for 2019 (51). Brain cancer incidence rates have declined slightly in recent years and mortality (death) rates have increased slightly (52).
There is great variability in survival by brain tumor subtype, and by age at diagnosis. Overall, the 5-year relative survival for brain cancers diagnosed from 2008 through 2014 was 33.2% (53). This is the percentage of people diagnosed with brain cancer who will still be alive 5 years after diagnosis compared with the survival of a person of the same age and sex who does not have cancer.
The risk of developing brain cancer increases with age. From 2011 through 2015, there were fewer than 4.5 brain cancer cases for every 100,000 people in the United States under age 65, compared with approximately 19.1 cases for every 100,000 people in the United States who were ages 65 or older (53).
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